Glenalmond, Hermiston and Weir Courts, in the Sighthill area of Edinburgh, are due to be demolished by controlled explosion on Sunday.
The move is part of a continuing regeneration effort in the area, which has already seen several other blocks demolished and new housing and facilities built.
Norman Work, vice convener of the health, social care and housing committee, who will also be at the demolition, said: “I know that many people will have fond memories of the North Sighthill flats but I’m also sure that most will recognise the need for progress and investment in the area.
“Sunday’s demolition is part of a programme of council-led investment worth up to £150m aiming to build 1,300 homes across the capital.
“This marks a major shift in our strategy that will boost the future of social housing in Edinburgh for the 21st Century.”
An exclusion zone will be put into place on Sunday, with the demolition being planned for around 11am or 12 noon. The three blocks, which were once home to 285 people, will be replaced by 320 new houses for sale or rent, half of which will be “affordable”.